Bring the clinic to your vanity with the ultimate protective shield.
The ZIPIDERM BioMatrix is a professional-grade hybrid cosmetic hydrogel face mask that translates advanced dermatological treatments into your daily at-home routine. Originally formulated for clinical skin soothing and barrier repair, this innovative peel-off liquid-to-film mask locks in intense moisture and multiplies active ingredient absorption, delivering resilient, clinic-quality glass skin from the comfort of your home.

Specially formulated as an intensive post-care treatment for professional aesthetic procedures like Ultherapy, Thermage, and Onda lifting. Clinical tests on laser-irritated skin proved its exceptional recovery power—delivering a 26.6x increase in skin soothing and a 10.8x improvement in barrier repair after just one single application.
Bring the clinic home. Lock in ultimate hydration and repair your barrier with our professional hydrogel face mask!
About Zipiderm
Discover zipiderm by Celltrion, a pharmacy-trusted bio-derma skincare brand designed to restore and maintain your skin’s natural health. Powered by advanced biotechnology and our exclusive Bio EGF™, our zero-irritation formula deeply repairs your skin from within.

Main Features
- Ultimate Post-Treatment Rescue: Clinically proven to provide rapid relief for laser-irritated skin, delivering up to 26.6x enhanced soothing and instantly rebuilding a compromised skin barrier after professional dermatological procedures.
- Clinic-Grade Hybrid Cosmetic: Originally developed for professional aesthetic programs to soothe irritated skin and repair compromised barriers, now optimized for premium at-home care.
- Advanced BioMatrix® Technology: Creates a seamless, breathable hydrogel film that locks in essential moisture and active nutrients.
- 28.8x Enhanced Absorption: Clinically proven to dramatically increase the penetration rate of skincare ingredients deep into the skin.
- 10.8x Less Ingredient Loss: Effectively prevents the evaporation of vital moisture and beneficial compounds.
- Premium Active Lineup: Available in 3 specialized formulas (EGF, PDRN, DVP) to target your specific skin concerns.
Why You’ll Love It
- Professional Barrier Repair at Home: Experience the exact hybrid cosmetic formulation used in premium esthetic programs. Designed to instantly soothe sensitivity and repair a compromised moisture barrier, this hydrogel face mask delivers professional-level skin recovery directly to your daily routine without the clinic price tag.
- BioMatrix® Absorption Mechanism: Upon application, it forms a transparent hydrogel film that blocks moisture evaporation. This unique barrier ensures active ingredients are continuously and deeply delivered into the skin without any loss.
- Clinically Proven Maximized Efficacy: Optimized to outsmart traditional skincare evaporation. It is proven to increase active ingredient absorption by up to 28.8 times while decreasing ingredient loss by 10.8 times.
Continuous, Zero-Loss Absorption Mechanism for Active Bio-Ingredients
A specialized formula designed to effectively deliver active bio-ingredients deep into the skin without evaporation. It stably provides essential nutrients to your skin, maximizing the overall skincare benefits.

- Conventional Flat-Structured Hydrogel: Rapidly releases ingredients in a short time, failing to deliver them deeply into the skin.
- BioMatrix® Self-Assembling Hydrogel: Locks in essential moisture and maximizes the continuous delivery of hydration and active bio-ingredients.
- Patented Self-Assembling Porous Hydrogel Technology: This innovative technology stably encapsulates active bio-ingredients to minimize loss. By maintaining an optimal moisture environment on the skin, it ensures that active ingredients are continuously absorbed, ultimately maximizing bioavailability.
When applied, the ZIPIDERM hydrogel face mask prevents moisture evaporation, ensuring active ingredients are stably and deeply absorbed into the skin for long-lasting results(Visible Results After Just 1 Week).

The Ultimate Hybrid Cosmetic for Glass Skin
Stop relying on traditional sheet masks that can dry out and draw moisture away from your face. The ZIPIDERM Hydrogel Facial Film is an advanced hybrid cosmetic bridging the gap between professional dermatology and daily home care. By acting as a dedicated protective shield, this hydrogel face mask ensures that 100% of your premium skincare investments reach deep within your skin layers. Experience authentic K-beauty innovation that visibly transforms your skin’s resilience, leaving it plump and deeply hydrated.

Originally used in professional treatment programs at Korean dermatology clinics, the Zipiderm Ex formula is now exclusively adapted for your at-home care.
Experience Clinic-Level Care at Home!

Experience 28.8x deeper absorption. Elevate your skincare routine with the ultimate hybrid cosmetic hydrogel face mask!
Choose Your Targeted Solution (Variants)
Discover the perfect hybrid cosmetic formula tailored to your specific skin concerns.
| Product Variant | Solution Title | Key Benefits | Recommended For | Ideal Post-Treatment For |
|---|---|---|---|---|
|
EGF (Green)
|
Skin Improvement Solution | Next-generation EGF for damaged skin barrier repair. | Post-care for professional barrier treatments. | RF Microneedling (e.g., Potenza), Fractional Lasers (e.g., Fraxel) |
|
PDRN (Pink)
|
Collagen Boosting Solution | Skin boosting for elasticity and lifting improvement. | Post-care for professional elasticity and lifting treatments. | Ultrasound/RF Lifting (e.g., Ultherapy, Thermage, Onda) |
|
DVP (Blue)
|
Skin Revitalizing Solution | Improvement of skin tone and overall elasticity. | Post-care for professional skin tone treatments. | Laser Toning, Pico Laser, and Brightening treatments |
- EGF (Green) – Skin Improvement Solution
- Target: Damaged Barrier Repair & Intensive Soothing
- Next-Generation EGF: Formulated with advanced epidermal growth factors to go beyond simple soothing. It actively rebuilds and repairs a compromised skin barrier from the inside out.
- Core Strengthening: Fortifies your skin’s natural defense mechanism, restoring its foundational strength to protect against future sensitivity and environmental stressors.
- 6.1x Greater Soothing Effect After Just One Use Post-Treatment.

- 10.8x Barrier Repair After Just One Use Post-Treatment (TEWL Improvement Rate)

- PDRN (Pink) – Collagen Boosting Solution
- Target: Elasticity Boosting & Lifting Effect
- Premium PDRN (Salmon DNA): Highly concentrated with Salmon DNA extract, a powerful regenerative ingredient that instantly infuses sagging, fatigued skin with vitality and bounce.
- Collagen Stimulation: As a premium PDRN mask, it deeply stimulates natural collagen production to increase skin density, visibly reducing the appearance of fine lines and delivering a flawless, firm texture.
- 9x Greater Skin Soothing After Just One Use Post-Treatment.

- 10.7x Barrier Repair After Just One Use Post-Treatment (TEWL Improvement Rate).

- 8.8% Improvement in Deep Skin Elasticity After Just 2 Weeks.

- DVP (Blue) – Skin Revitalizing Solution
- Target: Skin Tone Correction & Radiance
- Targeted Tone Care: Blended with a potent revitalizing complex to illuminate dull, uneven complexions, helping you achieve that coveted, translucent “glass skin” look.
- Total Revitalization: Awakens fatigued skin and restores an all-over luminous glow, returning life, brightness, and energy to tired skin cells.
- 26.6x Greater Skin Soothing After Just One Use Post-Treatment.

- 9.1x Barrier Repair After Just One Use Post-Treatment (TEWL Improvement Rate).

- 9.4% Improvement in Deep Skin Elasticity After Just 2 Weeks.

Main Ingredients
- PDRN (Premium Active): Extracted from Salmon DNA, it significantly enhances skin elasticity, deeply nourishes, and promotes the regeneration of a damaged skin barrier for a firmer complexion.
- CICA (Soothing Active): Provides rapid and intensive soothing care, reducing redness and calming sensitive or irritated skin.
- VITA (Brightening Active): Revitalizes dull skin and evens out tone, leaving a brilliant and radiant finish.
Skin Test
Post-Procedure Skin Soothing & Barrier Improvement Test for EGF Mask
- Clinical Research Center: Korea Institute of Dermatological Sciences
- Study Duration: Mar 09, 2026 (Measured after 1 use)
- Test Results: Demonstrated a 6.1x increase in skin soothing and a 10.8x improvement in the skin barrier after professional treatment.
Post-Procedure Skin Soothing & Barrier Improvement Test / Deep Skin Elasticity Test for PDRN Mask
- Clinical Research Center: Korea Institute of Dermatological Sciences
- Study Duration: Mar 04, 2026 – Mar 18, 2026
- Number of Subjects: 22
- Test Results: Demonstrated a 9x increase in skin soothing and a 10.7x improvement in the skin barrier after 1 use. Additionally, it showed an 8.8x improvement in deep skin elasticity after 2 weeks of use.
Post-Procedure Skin Soothing & Barrier Improvement Test / Deep Skin Elasticity Test for DVP Mask
- Clinical Research Center: Korea Institute of Dermatological Sciences
- Study Duration: Mar 05, 2026 – Mar 19, 2026
- Number of Subjects: 22
- Test Results: Demonstrated an exceptional 26.6x increase in skin soothing and a 9.1x improvement in the skin barrier after just 1 use. Additionally, it showed a 9.4x improvement in deep skin elasticity after 2 weeks of use.
Formulation
A smooth, fluid gel texture that easily glides onto the skin and transforms into a clear, flexible, and breathable hydrogel film as it sets.
How to use
- STEP 1: After cleansing, apply an appropriate amount of the gel evenly to targeted local areas or the entire face.
- STEP 2: Leave it on for about 20 minutes until it forms a dry, transparent film, then gently peel it off.

Recommended for
- Those who want to experience professional clinic-level skin soothing and barrier repair at home.
- Those who need a powerful moisture-locking barrier for dry, compromised, or sensitive skin.
- Those who want to maximize the absorption of their daily skincare regimen without evaporation.
- Those who are looking for a highly effective anti-aging treatment featuring a premium PDRN mask.
FAQ
- Q: What makes this hybrid cosmetic PDRN mask different from regular sheet masks?
A: Unlike traditional masks, our BioMatrix® liquid-to-film technology was originally developed for professional clinic programs. It creates a customized peel-off seal that blocks evaporation, pushing soothing and barrier-repairing nutrients up to 28.8 times deeper into the skin. - Q: Can I use this on a compromised skin barrier?
A: Absolutely. It was specifically formulated as a professional skin soothing and barrier repair treatment. The breathable hydrogel film protects the skin while it heals. - Q: How often should I use it?
A: For optimal clinic-level results, we recommend using it 2-3 times a week as an intensive treatment step in your skincare routine.













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