Transform your daily skincare routine with the Zipiderm EGF Skin Barrier Intensive Cream, a dermatologist-approved skin barrier care cream designed to rescue and rebuild sensitive, dry, and acne-prone skin. Powered by Celltrion’s exclusive Bio-EGF technology, this rich yet fast-absorbing formula instantly replenishes lost moisture and restores your skin’s natural defense, leaving you with a resilient, visibly firmer, and glowing complexion.

Is Your Skin Barrier Under Daily Attack?
Every day, your skin faces hidden stressors that silently weaken its natural defense:
- Environment: UV rays, fine dust, and AC/heating.
- Lifestyle: Stress, lack of sleep, and daily makeup friction.
Signs of a Compromised Barrier:
- Your skin feels noticeably drier and less firm than last year.
- Stubborn redness and breakouts heal much slower than usual.
The Solution: Your Daily Skin Barrier Care Rescue!
Stop waiting until the damage is already done. Proactive, daily skin barrier care is the secret to a healthy complexion. Our intensive skin barrier care cream transforms your routine by defending against daily environmental irritants, restoring lost elasticity, and soothing troubled, easily irritated skin from the inside out.

Experience 100 hours of flawless hydration with the ultimate skin barrier care cream!
About Zipiderm
Discover zipiderm by Celltrion, a pharmacy-trusted bio-derma skincare brand designed to restore and maintain your skin’s natural health. Powered by advanced biotechnology and our exclusive Bio EGF™, our zero-irritation formula deeply repairs your skin from within.

Main Features
- Doctor-Approved K-Dermatology Formula: This highly trusted skin barrier care cream is certified by dermatologists and available at premium Korean pharmacies and clinics.
- 100-Hour Lasting Deep Moisturization: Clinically proven to increase moisture levels by 537.24% immediately and lock it in for up to 100 hours without drying out.
- Proven Skin Barrier Repair: Visibly strengthens damaged skin barriers 6.75 times faster after a single use.
- Visible Elasticity Boost: Effectively improves dermis density by 7.24% and overall skin elasticity in just two weeks.
The true cause of lost firmness? A compromised skin barrier.

- EGF: The essential protein for strengthening the skin barrier and improving elasticity.
- Natural EGF levels decline sharply after your 20s.
This is why the EGF Intensive Cream is essential.
Why You’ll Love It
- Advanced Celltrion Bio-EGF™ for Maximized Absorption: Formulated with our proprietary high-purity EGF, this multi-layered nano-liposome structure enhances skin absorption by up to 170%. Delivering a 9x higher EGF protein concentration and a 150x boost in hyaluronic acid synthesis, this highly stabilized formula maintains its particle size for 100 days to maximize both deep moisture and elasticity.
- Fundamental Skin Barrier & Firmness Solution: Rapidly repairs a compromised skin barrier caused by external stressors and restores elasticity from the root. Enhanced with a synergy formula of Panthenol (10,000ppm), Ceramides, and plant-derived PDRN from roses, it effectively soothes skin troubles and provides a complete calming solution.
- Dermatologist-Tested & Safe for Sensitive Skin: Meticulously verified through expert dermatologist evaluations and rigorously tested for skin irritation. It delivers clinical-grade efficacy while remaining perfectly safe and gentle, even for highly sensitive or acne-prone skin.
- High-Density Texture for Ultimate Comfort: A tightly adhering, rich texture that smoothly wraps around the skin, providing deep nourishment without any sticky or heavy residue.

Say goodbye to dry, sensitive skin—discover 9x more power in this transformative skin barrier care cream!
Main Ingredients
- Celltrion Bio-EGF (sh-Oligopeptide-1, 1ppm): Dramatically boosts hyaluronic acid synthesis, repairs damaged skin barriers, and improves overall skin elasticity.
- Panthenol (10,000ppm): Provides intensive skin barrier care, deeply hydrating the skin and preventing moisture loss.
- Plant-Derived PDRN (Rose Extract): Offers deep hydration and revitalization, promoting a healthy-looking, youthful complexion.
- Ceramides & Bio-Film: Delivers concentrated moisture, locking in hydration and strengthening the skin’s natural protective shield.
- Hydrogenated Lecithin & Menadione: Effectively soothe sensitive and irritated skin, reducing redness and calming acne-prone areas.
Skin Test
Skin Elasticity Improvement Test
- Testing Agency: OACT Skin Clinical Trial Center
- Test Period: Sep 5, 2024 – Sep 19, 2024
- Subjects: 20 participants
- Test Results: Skin elasticity improved by 5.11%, Skin density improved by 7.24%, Itchiness caused by dryness relieved by 211.94%
Suitability for Acne-Prone Skin Test
- Testing Agency: Korea Institute of Dermatological Sciences
- Test Period: Dec 6, 2024 – Jan 13, 2025
- Subjects: 23
- Test Results: Inflammatory acne lesions reduced by 35.57%, Non-inflammatory acne lesions reduced by 23.78%, Sebum production reduced by 20.56%
Moisture Retention Test
- Testing Agency: OACT Skin Clinical Trial Center
- Test Period: Sep 2, 2024 – Sep 6, 2024
- Subjects: 22 participants
- Test Results: Skin redness caused by cumulative irritation reduced by 23.45%, Moisture retained at 189.48% after 100 hours (compared to pre-use)
Skin Barrier Improvement & Resilience Test
- Testing Agency: Korea Institute of Dermatological Sciences
- Test Period: Nov 5, 2024 – Nov 19, 2024
- Subjects: 20-22
- Test Results: Skin barrier resilience improved by 12.9%, Damaged skin barrier strengthened by 6.75x
Formulation
This high-density skin barrier care cream glides smoothly onto the skin, absorbing quickly without any stickiness to provide a plump, deeply nourished, and non-greasy finish.

How to use
- At the final step of your morning and evening skincare routine, dispense an appropriate amount of the skin barrier care cream.
- Gently apply and spread evenly along the skin’s texture.
- Tip 1: Apply evenly to dry areas on the body, such as arms and legs, for multi-care moisture.
- Tip 2: For exceptionally dry days, apply a thicker layer before bed to use it as an overnight hydration mask.

Recommended for
- Those who experience severe dryness or tightness from the inside out.
- Those who need to restore a severely damaged skin barrier.
- Those who are concerned about decreasing skin elasticity and fine lines.
- Those who want a safe, soothing skin barrier care cream suitable for acne-prone or sensitive skin.
- Those who prefer a rich, nourishing cream that leaves no sticky residue.
Ingredients
Water, Glycerin, Mangifera Indica (Mango) Seed Butter, Cetearyl Alcohol, Cetyl Alcohol, Dicaprylyl Carbonate, Hydrogenated Polydecene, Theobroma Cacao (Cocoa) Seed Butter, Polyglyceryl-3 Methylglucose Distearate, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glyceryl Stearate, Propanediol, C12-16 Alcohols, 1,2-Hexanediol, Panthenol, Raffinose, Palmitic Acid, Hydrogenated Lecithin, Ammonium Acryloyldimethyltaurate/VP Copolymer, Glyceryl Caprylate, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Caprylic/Capric Triglyceride, Xanthan Gum, Adenosine, Anthemis Nobilis Flower Oil, Disodium EDTA, Polyquaternium-51, Ceramide NP, Thuja Occidentalis Leaf Extract, Octyldodecanol, Citrus Aurantium Amara (Bitter Orange) Flower Extract, Glyceryl Acrylate/Acrylic Acid Copolymer, Brassica Campestris (Rapeseed) Sterols, Sodium PCA, Stearic Acid, Olea Europaea (Olive) Fruit Oil, Bentonite, Ribes Nigrum (Black Currant) Seed Oil, Cyclohexasiloxane, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Dipropylene Glycol, Olive Oil Decyl Esters, Hydroxyacetophenone, Phytosphingosine, Citric Acid, Dioleoyl PEG-50/PPG-10/Dimethicone, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, sh-Oligopeptide-1 (1ppm), Polylactic Acid, Polyglyceryl-10 Diisostearate, Squalane, Ceramide NS, Cholesterol, Chlorella Vulgaris Extract, Ceramide AP, Ceramide AS, Menadione, Rosmarinus Officinalis (Rosemary) Leaf Extract, Sodium DNA, Sea Salt, Ceramide EOP.
FAQ
- Q1: Is this skin barrier care cream safe for acne-prone skin?
A: Yes, it has completed non-comedogenic testing and is clinically proven to reduce both inflammatory and non-inflammatory acne lesions, making it highly suitable for acne-prone and sensitive skin. - Q2: Will this cream feel heavy or sticky?
A: Not at all. Despite its rich, high-density texture, it features nano-liposome technology for a 170% improved absorption rate, leaving a smooth, non-sticky finish. - Q3: How long does the hydration last?
A: The cream is clinically proven to provide 100-hour lasting deep moisturization, maintaining a 537.24% increase in moisture levels even after 100 hours.














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