The most powerful anti-aging cream made by a pharmaceutical company, Dongkook Pharmaceutical’s 46 years of dermatological science technology have been combined to create Madeca Cream in 2015, followed by Madeca Cream Active Skin Formula, which was renewed in 2020, and The Madeca Cream, which was renewed again in 2021.
In November 2023, Dongkook Pharmaceutical launched Madeca Cream Time Reverse, which greatly improved the efficacy of Madeca Cream by applying Dongkook’s unique centella asiatica science, TECAnology™.
Click here to see details about The Madeca Cream 50ml (Season 6)
Click here to see details about Madeca Cream Active Skin Formula (Season 5)
Based on its long-standing pharmaceutical technology, Dongkook Pharmaceutical has expanded its business area to the Cosmeceutical category, which combines cosmetics and pharmaceuticals, and is achieving great success.
Did you know that signs of aging on your skin accumulate as you age?
- Skin becomes dry frequently due to lack of moisture.
- Wrinkles become deeper.
- Melasma and blemishes increase.
- Skin elasticity decreases.
- Pores become larger.
- Skin becomes easily irritated and sensitive.
- Skin tone becomes darker.
- Skin texture is not smooth.
- Fine & small dead skin cells on your skin peel off.
- Skin radiance decreases.
If your skin shows at least one of the above signs of aging, try Madeca Cream Time Reverse!
The ultimate anti-aging cream, Madeca Cream Time Reverse, has been upgraded to be even more powerful!

Centellian24 is a derma cosmetic brand created in 2015 by Dongkook Pharmaceutical Co., Ltd., the pharmaceutical company that developed “Madecassol,” a representative wound treatment in Korea that has been sold since 1970, by incorporating TECA (Titrated Extract of Centella Asiatica), the core ingredient of Madecassol, into skincare. Madeca Cream is a highly functional cosmetic brand that has recorded cumulative sales of approximately $600 million and cumulative sales of 52 million units since its launch in April 2015.
Main Features
- Total anti-aging cream with overwhelming efficacy meticulously designed through 100 clinical trials!
- A total solution that improves the overall signs of aging on your skin with just one cream!
- Contains ACTIVE-TECA™ 30,000ppm, which is a fusion of 5 patented technologies.
- Contains 12 types of special ingredients from Centella Asiatica.
- Premium formulation is applied to be absorbed deep into the skin in just 5 seconds
- Completed 4 types of skin stability tests.
Madeca Cream Time Reverse meticulously designed through 100 clinical trials including 26 tests for improving wrinkles and lifting, high-density/high-strength elasticity and moisturizing, and improving freckles, skin tone, and radiance, provides overwhelming efficacy that comprehensively cares for 10 signs of skin aging!
26 Tests for Wrinkle and Lifting Improvement

Moisture test

High-intensity skin elasticity and moisture test

Melasma and blemishes, skin tone, and skin glow test

How does the cream combined with Active-TECA differ?
- Can feel the effect in just 5 seconds
- Absorption speed is twice as fast as The Madeca Cream
- Moisturizes up to 15 layers below the epidermis
- Improves elasticity of 30 sagging skin areas at the same time
- Sustains moisture, elasticity, and radiance for 240 hours
Main Ingredients
- Active-TECA 30000ppm: TECA ingredients are absorbed deeply and quickly into the three layers under the skin.
- The three major components of the skin: Collagen (Collagen Amino Acids), Elastin (Hydrolyzed Elastin), Hyaluronic acid (Sodium Hyaluronate)
- 3 patented moisturizing ingredients
- AQUAXYL®(Patent number US 8088742: B2Xylitylglucoside), Anhydroxylitol , Water, Xylitol, Glucose)
- ECTOIN(Patent number US 8598346 B2, EP 1641459 B1)
- GLYCOGEN(Patent number 10-2214865, WO 2014172768)
Contains 12 special Centella asiatica ingredients that contain Dongkook Pharmaceutical’s research know-how from 55 years of Centella asiatica research.

Formulation
It is a white anti-aging cream formulation with added protein extracted from Centella asiatica, which gives it a thick and sticky feel. When applied to the skin, it melts with the temperature of your hand and spreads very smoothly on the skin, and is a formulation that is quickly absorbed into the skin.

Skin Test
Completed 4-step skin safety test including sensitive skin, acne-prone skin, skin irritation test, and German dermatest. Completed 4 types of skin safety tests targeting sensitive skin
- Test Institute: Korea Institute Of Dermatological Sciences Co., Ltd.
- Test Period: Sep 11, 2023 to Sep 14 2023
- Test Subjects: 35
- Test Results: The subjects were patch tested with this cream on their skin for 24 hours, then removed it, and their skin condition was monitored 30 minutes, 24 hours, and 48 hours later, confirming that it was safe to use on sensitive skin.
Suitability Test for Acne-Prone Skin
- Test Institute: Korea Institute Of Dermatological Sciences Co., Ltd.
- Test Period: Sep 5, 2023 to Oct 14 2023
- Test Subjects: 21
- Test Results: This cream was tested on the skin of subjects with acne-prone skin for 4 weeks and confirmed that it was suitable for their use.
Skin irritation Test
- Test Institute: Korea Institute Of Dermatological Sciences Co., Ltd.
- Test Period: Aug 7, 2023 to Aug 10, 2023
- Test Subjects: 33
- Test Results: The subjects were patch tested with this cream on their skin for 24 hours, and their skin condition was monitored 30 minutes, 24 hours, and 48 hours after removal, confirming that it was a product without skin irritation.
Dermatest in Germany
- Test Institute: Dermatest GmbH(Germany)
- Test Period: Sep 19, 2023 to Sep 22 2023
- Test Subjects: 30
- Test Results: The subjects were patch tested with this cream on their skin for 24hours, and their skin condition was monitored 30 minutes, 24 hours, and 48 hours after removal, resulted in an Excellent grade.

How to use
- After washing your face in the morning and evening, apply an appropriate amount to your face as the last step of your skincare routine and gently spread it over your entire face.
- Tip: When you need special skin care for the next day, apply a thick layer of cream over your entire face as the last step of your skincare routine before going to bed, and you will experience amazing results the next day.
Recommended for
- Those who want to improve melasma.
- Those who want to improve wrinkles.
- Those who want to improve the size of enlarged pores.
- Those who want to relieve skin aging caused by UV rays.
- Those who want to make their skin look younger.
- Those who want to make their skin elastic.
Ingredients
Water, Dipropylene Glycol, Hydrogenated Plidescene, Caprylic/Caprylic Glyceride, Glycerin, Glycerylstearate, Pentaerythridyltetraetherhexanoate, Niacinamide, Cyclohexasiloxane, Cetyl Alcohol, Polyglyceryl-6 Dystearate, Vinyl Dimethicone, Dicapryl Ether, Bottle-Pull Protein Extract, Asiaicoside, Asiaic Acid, Madeka Acid (4,800 Ppm), Bottleful Oil, Bottleful Amino Acid, Madecaside, Ascoville Asiatate, Bottleful Polypeptide, Hydrolized Hyaluronic Acid, Hydrolized Bottleful Acid, Bottleful Acid, Bottleful Acid Extract, Lacemosa Riding Root Extract, White-Patterned Orchid Extract, Macadamia Sea Oil, Stone Soybean Oil, Hydrogenated Lecitan, Sodium Hyaluronate, Polyglyceryl-10 Laurate, Stearyl Alcohol, Bizwax, Sodium Stearoylglutamate, Panthenol, Xylglucoside, Hydroxyethyldimethyltaurate Copolymer, Hojobaester, Anhydroxylitol, Butylene Glycol, Polyglyceryl-3bizwax, 1,2-Hexanediol, Hydroxyacetophenone, Xylidol, Methylpropanediol, Allantoin, Propanediol, Candida Bombicola/Glucose/Methylleifacidated Ferment, Xanthan Gum, Ethoxidiglycol, Dysodium Dithi, Glucose, Adenosine, Solbitan Isostate, Ethylhexylglycerin, Sodium Laurate, Cyclodextrin, Lowriacid, Sodium Polyacrylate, Pvm/Macopolymer, Octidodecanol, Glycopidolipid, Caffeine, Glucoripid, Adenosine, Solbitan Isostate, Ethylhexylglyceride, Sodiumaglyceride, Sodium, Cyclodextrin, Lowriacid, Sodium Polyacrylate, Sodium Polyacrylate, Pvm/Macpolycopolymer, Octyldocan, Glyldocanol, Glycopid, Glycopidol, Glycopide, Glycopid, C12-13 Fares-9, Collagen Amino Acid, Serra Maidenp, Resveratrol, Algin, Glycogen, Ectoin, Taurine, Hydrolized Elastin, Retinol, Maltodextrin, Phytodextrin, Sucrose Dystearate, Sodium Dna, Cyanocobalamin, Glycine, Glutamic Acid, Sunflower Seed Wax, Polyglycerin-3, Tocopherol, Bitter Mugwort Extract, Vanilla Fruit Extract, Olive Oil, Orange Oil, Philippine Orange Peel Oil, Lavender Oil, Bergamot Oil, Rosemary Leaf Oil, Orange Peel Oil, Lycene Fruit Oil, Pencil Juniper Oil, Atlascida Bark Oil, Sentinium Flower Oil, Common Jasmine Oil, Martel Oil, Rose Oil, Galvanum Resin, Balsamcopa Resin, Limonene, Linalul, Citral (Active-Teca 30,000 Ppm)
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Madeline Cross –
Hearing that this new version offers nearly double the efficacy, I immediately picked it up for my extremely dry skin. Compared to the classic Madeca cream, it absorbs much faster, glides on smoother, and has a weightless texture that never feels suffocating. It keeps my foundation from flaking or caking flawlessly. If I had to pick one downside compared to the original, the protective oil barrier feels a tad thinner.
Harper Vance –
I have oily skin that suffers from severe deep inner-skin dryness. Whenever I tried heavy, greasy products to fix the inner dryness, it inevitably triggered sudden breakouts and pimples?honestly the worst skin condition ever. But this cream is an absolute miracle. It locks in deep moisture seamlessly while visibly firming my skin. I am strictly sticking to this tube from now on.
skincare_devotee –
This feels like the ultimate summer edition of the Madeca Cream line. It has absolutely zero sticky aftermath, yet it makes my morning makeup lock into place beautifully without sliding off. Highly satisfied.
Zoe Bennett –
Since we are in the peak of summer, I was hunting everywhere for a weightless, non-sticky moisturizer. This cream is exactly what I needed?completely fresh and zero tacky residue, yet intensely hydrating!
Lydia Henderson –
This was my first time trying this specific formula. The blendability is outstanding, and despite my chronically dry skin, this cream keeps my face deeply hydrated for 24 hours straight without a single dry patch!! It is a perfect four-season staple.
Eleanor –
Both the silky application and the absorption efficiency are top-tier. It preps my skin barrier flawlessly before jumping into my morning vanity routine.
Hazel Cross –
The moment it melts in, it deeply penetrates parched skin layers to erase all traces of dehydrated inner-skin tightness. You can honestly feel the moisture barrier building up from within.
Sienna Taylor –
It features an incredibly unique, sorbet-like soft, bouncy texture. It has a very faint, pleasant clean scent that is practically fragrance-free. Slathering on a generous layer before bed leaves my face completely plump, free of dry tightness, and coaxes out a gorgeous, lit-from-within glow by morning.
Vivian M. –
It keeps my face beautifully plump and bouncy while noticeably smoothing and catching the wrinkles around my forehead and mouth area. My overall complexion looks significantly brighter, clearer, and more rejuvenated.
Audrey P. –
The moisture retention and deep hydration are outstanding. Patting it on during my morning skincare routine creates a beautiful base, and layering a thick coat after my night cleanse leaves my skin incredibly soft, plump, and healthy the next day. Truly loves it.